WebA dose of 1.5 - 2.2 mg/kg provides an additional 6 - 8 minutes of anesthesia in unpreanesthetized dogs. Clinical response may vary, and is determined by the dose, rate of administration, and frequency of maintenance injections. ALFAXAN MULTIDOSE maintenance dose sparing is greater in dogs that receive a preanesthetic. Webalfaxalone and 0.1mg/kg medetomidine or 20mg/kg alfaxalone and 0.05mg/kg medetomidine) in the Horsfield’s tortoise (Agrionemys horsfieldii). The effects were rapid in onset and dose-dependent with variable individual effects. A dose of 10mg/kg alfaxalone resulted in light to moderate sedation with no analgesia and
Medical technology Vaxinano
http://repositorio.udec.cl/handle/11594/4191 Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan, is a neuroactive steroid and general anesthetic which is used currently in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic. Though it is more expensive than other … See more Alfaxalone is used as an induction agent, an injectable anesthetic, and a sedative in animals. While it is commonly used in cats and dogs, it has also been successfully used in rabbits, horses, sheep, pigs, and exotics such as See more Alfaxalone has relatively few side effects compared to other anesthetics; most notable is its lack of cardiovascular depression at clinical doses, which makes it unique among … See more Pharmacodynamics Alfaxalone is a neuroactive steroid derived from progesterone, though it has no glucocorticoid or mineralocorticoid action. Instead, it works by … See more In 1941, progesterone and 5β-pregnanedione were discovered to have CNS depressant effects in rodents. This began a search to … See more Alfaxalone has been used to perform C-sections in pregnant cats; though it crosses the placental barrier and had some effects on the kittens, there is no respiratory depression and no … See more The quick metabolism and elimination of alfaxalone from the body decreases the chance of overdose. It would take over 28 times the normal … See more Alfaxalone, also known as 11-oxo-3α,5α-tetrahydroprogesterone, 5α-pregnan-3α-ol-11,20-dione, or 3α-hydroxy-5α-pregnane-11,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. It is specifically a modification of … See more cc wallpapers
Development of vaccines Vaxinano
Weba general anesthetic. Alfaxalone is chemically described as 3 α hydroxy 5 α pregnane 11, 20dione, and has a molecular weight of 332.5. The primary mechanism for the anesthetic action of alfaxalone is modulation of neuronal cell membrane chloride ion transport, induced by binding of alfaxalone to GABAA (gammaaminobutyric acid) cell surface ... WebAlfaxalone (3α-hydroxy-5α-pregnane-11,20-dione) is a synthetic neuroactive steroid used to induce and maintain general anesthesia. The anesthetic properties of alfaxalone have … WebIn dogs, the mean terminal plasma elimination half-life (t1/2) for alfaxalone is approximately 25 minutes for a 2 mg/kg dose. Plasma clearance for a 2 mg/kg dose is 59.4 ± 12.9 … butchers werribee