WebSep 27, 2024 · Activating translation by phase separation: a novel mechanism for driving spermiogenesis September 2024 Authors: Wenjing Zhang Yang Wang University of North Carolina at Chapel Hill Request... WebFeb 14, 2024 · Fragile X mental-retardation protein (FMR1) binds target mRNAs to form ribonucleoprotein (RNP) complexes/granules that control various biological processes, …
Liquid-liquid phase separation underpins the formation of …
WebAug 12, 2024 · Germline-specific Fxr1 ablation in mice impaired the translation of target mRNAs and caused defective spermatid development and male infertility, and a phase … WebAug 12, 2024 · Germline-specific Fxr1 ablation in mice impaired the translation of target mRNAs and caused defective spermatid development and male infertility, and a phase separation-deficient FXR1 L351P mutation in Fxr1. Animals. Gene Expression … instalar google chrome en surface
FXR1 splicing is important for muscle development and …
WebMuscle-specific FXR1 isoforms contain a longer primary sequence than in other tissues, with a predicted 300-aa-long intrinsically disordered domain (IDD) at the C terminus. Numerous RBPs contain disordered or low-complexity sequences that are associated with biomolecular condensation or liquid–liquid phase separation (LLPS; Banani et al., 2024 ). WebThe study reported that the RNA-binding protein FXR1 can activate the translation of mRNA in late sperm cells of mice by liquid-liquid phase separation, ensuring the normal progress of the sperm formation process. ... Activating translation with phase separation, a professor at the French Institute of Human Genetics, published in Science ... WebFeb 14, 2024 · FMR1 is a ribosome-associated RBP, and its selectivity for RNA targets largely depends on two central KH domains and a C-terminal (RGG) box 12, 13. In addition, the Agenet domains and the KH0 motif... jewelry supply stores in phoenix az