WebBackground and aims Huntington’s Disease (HD) is a neurodegenerative condition caused by abnormal expansions (>37) of a polyglutamine (PolyQ) tract in the huntingtin protein … WebInclusion Bodies COS Cells Neurons Intranuclear Inclusion Bodies Cell Line Brain Blood Platelets PC12 Cells Cell Nucleus Cells, Cultured HEK293 Cells Cytoplasm Lens, Crystalline Neurofibrillary Tangles HeLa Cells Endoplasmic Reticulum Purkinje Cells Mitochondria Cell Line, Tumor Cell Membrane Hippocampus Pharyngeal Muscles Corpus Striatum ...
An N-terminal Nuclear Export Signal Regulates Trafficking and ...
WebHuntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice WebCompetition for the polyQ site by the antibody would, presumably, free up more Hip-1 for interaction with Hippi. Yeast Needs Microtubules to Make Inclusion Bodies. The … simple scalloped potatoes food network
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WebRecent studies have implicated an N-terminal caspase-6 cleavage product of mutant huntingtin (htt) as an important mediator of toxicity in Huntington's disease (HD). To directly assess the consequences of such fragments on neurologic function, we produced transgenic mice that express a caspase-6 length N-terminal fragment of mutant htt … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebHuntington disease (HD) is caused by an expanded polyglutamine (poly(Q)) repeat near the N terminus of the huntingtin (htt) protein. Expanded poly(Q) facilitates formation of htt aggregates, eventually leading to deposition of cytoplasmic and intranuclear inclusion bodies containing htt. ray charles and mary ann fisher